PARK11 is not linked with Parkinson's disease in European families

Prestel J., Sharma M., Leitner P., Zimprich A., Vaughan J., Durr A., ...Daha Fazla

EUROPEAN JOURNAL OF HUMAN GENETICS, cilt.13, sa.2, ss.193-197, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1038/sj.ejhg.5201317
  • Dergi Adı: EUROPEAN JOURNAL OF HUMAN GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-197
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.