PARK11 is not linked with Parkinson's disease in European families
EUROPEAN JOURNAL OF HUMAN GENETICS, cilt.13, sa.2, ss.193-197, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 2
- Basım Tarihi: 2005
- Doi Numarası: 10.1038/sj.ejhg.5201317
- Dergi Adı: EUROPEAN JOURNAL OF HUMAN GENETICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.193-197
- İstanbul Üniversitesi Adresli: Hayır
Özet
Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.