PARK11 is not linked with Parkinson's disease in European families

Prestel J., Sharma M., Leitner P., Zimprich A., Vaughan J., Durr A., ...More

EUROPEAN JOURNAL OF HUMAN GENETICS, vol.13, no.2, pp.193-197, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1038/sj.ejhg.5201317
  • Journal Name: EUROPEAN JOURNAL OF HUMAN GENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.193-197
  • Istanbul University Affiliated: No

Abstract

Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.