This study was carried out Munzur River between May 2015 and June 2016 in order to determine the benthic macroinvertebrate fauna, physicochemical parameters and water quality, by applying BMWP, ASPT and IBPAMP biotic index. In this study, we aimed to approach the water quality of Munzur River and contribute to our biological inventory. Benthic macroinvertebrate individuals were collected from six sites. A total of 37 taxa and 2459 individuals were identified, 33 taxa belonging to Insecta, 2 taxa belonging to Gastropoda, 2 taxa belonging to Malacostraca. Also, some physicochemical parameters of the water (Dissolved oxygen, pH, NO2-N, NO3-N, Ca, flow rate, NH4-N, temperature) were analyzed. As a result of our research the highest ASPT index value was found in the fourth station, the IBPAMP index value was found in the fifth station and BMWP index value was determined in the second station. According to BMWP, ASPT, IBPAMP index and physicochemical parameters results, the water quality of Munzur River was found to unpolluted/slightly polluted. First in all species and physicochemical measurements recorded for the region so there is need for much intensive investigation and further testing of the effectiveness of the BMWP, ASPT and IBPAMP indices.