Akademik Veri Yönetim Sistemi
Revista da Associacao Medica Brasileira, cilt.72, sa.1, 2026 (SCI-Expanded, Scopus)
OBJECTIVE: Juvenile idiopathic arthritis is the most common chronic arthritis in children and adolescents. Nitric oxide mediates autoimmune responses and plays a role in the etiology of numerous rheumatic diseases. Endothelial nitric oxide synthase regulates nitric oxide levels through catalyzing its production. Here, we evaluated the effect of eNOS rs1799983 and variable number tandem repeat variants on disease occurrence and clinical findings in Turkish juvenile idiopathic arthritis patients. METHODS: One hundred and eight participants, including 58 juvenile idiopathic arthritis patients and 50 healthy controls, were included in the study. eNOS rs1799983 and variable number tandem repeat variants were genotyped using polymerase chain reaction and/or restriction fragment length polymorphism. The genotype distribution of the patients was investigated according to their clinical and laboratory results. The results of the analyses were evaluated for statistical significance. RESULTS: The eNOS genotype distributions did not differ between juvenile idiopathic arthritis patients and controls. Within the patient population, those carrying the rs1799983 GT/TT genotypes had higher body mass index, whereas those with the VNTR 4b/4b genotype had lower sedimentation rate. CONCLUSION: Our study results suggest that the eNOS rs1799983 and variable number tandem repeat variants may play a role in juvenile idiopathic arthritis patients’ clinical findings. These data need to be confirmed in different ethnic and larger sample groups.