Akademik Veri Yönetim Sistemi
Diğer, ss.1-16, 2024
Over the past century, the emergence of antibiotic-resistant bacterial strains has heightened interest in bacteriophages. Advances in genomic engineering techniques have expanded the potential applications of phages across various fields. However, the long-term effects of phage therapy on the human body remain poorly understood. As a result of this study, a target constant region that is responsible for coding of the overcome classical restriction (Ocr) protein on T7 phage that provides protection from restriction enzymes was detected. A molecule called Riboflavin that interacts with this region could be used in the clearance of T7 phages. In addition, another docking study revealed that Ocr has an antitranscriptive effect on the Human Early B-cell Factor 1 (EBF1) DNA-binding domain, which affects the cellular processes. Confirmation of these findings by further clinical and in vitro studies will provide new insights into phage-human cell interactions and new phage-clearing treatments.