Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: The role in different clinical manifestations of venous thromboembolism

Okumus G., Kiyan E., Arseven O., Tabak L., Diz-Kucukkaya R., Unlucerci Y., ...Daha Fazla

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.14, sa.2, ss.168-173, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1076029607305620
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.168-173
  • Anahtar Kelimeler: factor V Leiden, prothrombin 20210A, natural anticoagulant, pulmonary embolism, deep vein thrombosis, FACTOR-V-LEIDEN, DEEP-VEIN THROMBOSIS, PLASMA PROTHROMBIN LEVELS, ACTIVATED PROTEIN-C, PULMONARY-EMBOLISM, INHERITED THROMBOPHILIA, G20210A MUTATION, PREVALENCE, POPULATION, GENE
  • İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (NIT E) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G 169 1A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P =.003 and P =.02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P =.04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.