Hereditary thrombophilic risk factors and venous thromboembolism in Istanbul, Turkey: The role in different clinical manifestations of venous thromboembolism

Okumus G. , Kiyan E. , Arseven O. , Tabak L., Diz-Kucukkaya R., Unlucerci Y. , ...More

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.14, no.2, pp.168-173, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1177/1076029607305620
  • Page Numbers: pp.168-173


The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (NIT E) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G 169 1A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P =.003 and P =.02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P =.04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency.