Objective: The purpose of this study was to identify the 100 top-cited articles in endodontics and analyse their bibliometric characteristics. Material and methods: The Web of Science database was reviewed to identify the relevant articles. Results: One hundred and three articles were included because the last four articles had the same number of citations. The top-cited article received 2115 citations. The articles were published in 28 different journals, with the most popular publication being the Journal of Endodontics (n = 36). The most prolific country was the United States (n = 41), followed by Sweden (n = 17) and Switzerland (n = 8). The most prolific author and institution were M. Torabinejad (n = 12) and Umea University (n = 9), respectively. The majority of articles were of a basic science nature (n = 55), while endodontic microbiology (n = 24) was the most frequent subspecialty. The most common study design used in clinical articles was non-randomized experimental study (n = 5). Half of the clinical articles (n = 11) had a level III evidence score. Conclusions: The present citation analysis provides insights into the historical progress and current trends in endodontics.