Akademik Veri Yönetim Sistemi
12th International Drug Chemistry Congress, Antalya, Türkiye, 7 - 10 Mart 2024, ss.126
Spiro compounds are bicyclic or polycyclic organic molecules containing saturated rings connected
through a shared atom. Spirothiazolidinone (1-thia-4-azaspiro[4.5]decan-3-one) spirocyclic ring
system is a structure that is frequently used in biologically active compounds synthesized in our
laboratory. It has been determined that compounds containing the '2-methyl-1-thia-4-
azaspiro[4.5]decan-3-one' ring system bind to the influenza virus hemagglutinin glycoprotein and
show activity by preventing the fusion of the virus with the cell membrane (1-4). 5-Chloro-3-methyl-
1H-indol-2-yl derivative spiro compounds have come to the fore as the most active members of the
fusion inhibitor series (5). While studies on influenza viruses continue, some of the new compounds
synthesized and tested in recent years have been found to be effective against human HCoV-229E,
which is in the genus α-coronavirus (6,7). In this research, we have designed new spirothizolidinone
derivatives carrying an indole moiety. New indole-spirothiazolidinone derivatives synthesized and
purified according to the literature methods and the molecular structures determined by elemental
analysis and spectral analysis (IR, 1 H-NMR, 13 C-NMR, MS/ESI). Compounds were tested for anti-
influenza virus activity in MDCK cells and anti-coronavirus (HCoV-229E) activity in HEL cells.