Effect of Garcinia cambogia Extract on Fatty Liver in Rats Fed High Lipid


Ates A., Gursel F. E., Altiner A., Bilal T., Erdogan O., Ozyogurtcu H.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.17, sa.6, ss.1015-1020, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2011
  • Dergi Adı: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1015-1020
  • İstanbul Üniversitesi Adresli: Evet

Özet

Garcinia cambogia is a plant which contains hydroxycitric acid and suppresses appetite and body fat accumulation. The aim of the study was to investigate the improving effect of Garcinia cambogia-extract on liver phospholipid, triglyceride, lipid hydroperoxide, total protein and gamma-glutamyltransferase (GGT) activity, and histopathology of liver in female rats fed high-lipid diet. One-year-old 30 female Sprague-Dawley rats were separated to three equal groups. Group 1 (control group) was fed basal diet (2% liquid vegetable oil, 0% cholesterol), while the diets of both group 2 and 3 contained vegetable oil (2% liquid and 5% hydrogenated vegetable oil) and cholesterol (3%). 4.5% (W/W) Garcinia cambogia-extract was added to the diet of group 3 from day 45. Rats were euthanized on day 75. Liver samples were weighed, homogenized and centrifuged to obtain post-mitochondrial fractions (PMF). PMF phospholipid levels significantly decreased in the group fed high-lipid diet compared with the control group and in the group fed Garcinia cambogia-extract compared with the other two groups (P<0.05). PMF lipid hydroperoxide levels were significantly higher and PMF triglyceride levels were significantly lower in the control group than those in the other two groups (P<0.05). In the result of histopathological examinations, marked fat infiltration was observed in hepatocytes of animals fed high-lipid diet. Livers of animals fed Garcinia cambogia-added diet showed moderate fat infiltrations of the hepatocytes. Liver fattening partly occurred in rats fed high-lipid diet. However, this did not lead to the severe cellular degeneration. Garcinia cambogia added to the high-lipid diet insufficiently impaired liver fattening in the present dose.