Fixed drug eruption: state of the art
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, cilt.6, sa.3, ss.181-188, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 3
- Basım Tarihi: 2008
- Doi Numarası: 10.1111/j.1610-0387.2007.06491.x
- Dergi Adı: JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.181-188
- İstanbul Üniversitesi Adresli: Evet
Özet
Fixed drug eruption (FIDE) is a common type of cutaneous adverse drug reaction. There may be a genetic background as significant associations have been identified between HLA types and specific FDE. Systemic provocation is still the gold standard for establishing the offending agent in FIDE, but topical provocation testing offers a promising alternative approach. A standardized method does not exist, and the approach must likely be varied for different agents. The mystery of site preference in FIDE is still unresolved. Possible explanations include properties of the drug, trauma and viscerocutaneous reflex patterns.