AG-NOR STUDIES IN A HUMAN LYMPHOCYTE CULTURE - ARE VARIANTS LOCALIZED TO SPECIFIC CHROMOSOMES


ÖZEN M., HOPWOOD V., PATHAK S.

AMERICAN JOURNAL OF MEDICAL GENETICS, cilt.59, sa.2, ss.225-228, 1995 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1002/ajmg.1320590220
  • Dergi Adı: AMERICAN JOURNAL OF MEDICAL GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.225-228
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The genomic activity and polymorphisms of nucleolus organizer regions (NORs) were studied in an individual with routinely used AgNO3 and Q-banding techniques. The results demonstrate that (a) the mean number of NORs per metaphase spread was 7.4, (b) chromosomes 14, 13, 15, and 21 showed variations of Ag-NOR in decreasing order, (c) chromosome 22 did not show a polymorphism in any cell examined, and (d) both chromosomes 14 showed silver staining in most cells, Unlike many earlier reports indicating that NOR variants were constitutional in each individual, our present case represented a mosaic pattern of polymorphism involving most of the D- and G-group chromosomes. (C) 1995 Wiley-Liss, Inc.