Immunosuppressive therapy in lupus nephritis - The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide

HOUSSIAU, FA; VASCONCELOS, C; D'CRUZ, D; SEBASTIANI, GD; GARRIDO, ED; DANIELI, MG; ABRAMOVICZ, D; BLOCKMANS, D; MATHIEU, A; DIRESKENELI, H; GALEAZZI, M; Gul, Ahmet; LEVY, Y; PETERA, P; POPOVIC, R; PETROVIC, R; SINICO, RA; CATTANEO, R; FONT, J; DEPRESSEUX, G; COSYNS, JP; CERVERA, R

doi:10.1002/art.10461

Immunosuppressive therapy in lupus nephritis - The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide

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HOUSSIAU F., VASCONCELOS C., D'CRUZ D., SEBASTIANI G., GARRIDO E., DANIELI M., ...More

ARTHRITIS AND RHEUMATISM, vol.46, no.8, pp.2121-2131, 2002 (SCI-Expanded)

Publication Type: Article / Article
Volume: 46 Issue: 8
Publication Date: 2002
Doi Number: 10.1002/art.10461
Journal Name: ARTHRITIS AND RHEUMATISM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2121-2131
Istanbul University Affiliated: Yes

Abstract

Objective. Glomerulonephritis is a severe manifestation of systemic lupus erythematosus (SLE) that is usually treated with an extended course of intravenous (IV) cyclophosphamide (CYC). Given the side effects of this regimen, we evaluated the efficacy and the toxicity of a course of low-dose IV CYC prescribed as a remission-inducing treatment, followed by azathioprine (AZA) as a remission-maintaining treatment.