Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults


Komurcu-Bayrak E. , Onat A., Poda M. , Humphries S. E. , Palmen J., Guclu F. , ...Daha Fazla

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.46, ss.778-784, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1515/cclm.2008.161
  • Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Sayfa Sayıları: ss.778-784

Özet

Background: Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 -1131T > C and c.56C > G polymorphisms [single nucleotide polymorphism (SNP)] with serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] and the risk for metabolic syndrome (IMS) in the Turkish Adult Risk Factor study.

Abstract

BACKGROUND:

Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 -1131T>C and c.56C>G polymorphisms [single nucleotide polymorphism (SNP)] with serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] and the risk for metabolic syndrome (MS) in the Turkish Adult Risk Factor study.

METHODS:

We genotyped SNPs using the Taqman allelic discrimination assays in 1564 Turkish adults (51.4% female, mean age 54.1+/-11.6 years). MS and dyslipidemia were defined using the criteria of the National Cholesterol Education Program.

RESULTS:

For both SNPs, rare allele carriers had significantly higher fasting triglyceride levels in both genders, except the c.56G allele in men. The -1131C allele was associated with lower HDL cholesterol (HDL-C) levels in women. In relation to dyslipidemia, the c.56C>G and haplotype 1 had significant gender-genotype interactions (p<0.05). Otherwise, both SNPs were significantly associated with dyslipidemia after adjustment for risk factors in women. After similar adjustment, non-carriers of the haplotype 1 (odds ratio=4.1, p=0.003) increased the MS risk in women. However, no significant associations emerged between SNPs and HDL-C, dyslipidemia or MS in a similar analysis in men.

CONCLUSIONS:

Excess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women.