Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population.

Zeliha K. P., Dilek O., Ezgi O., Halil K., Cihan U., Gul O.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, vol.28, no.2, pp.215-219, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jsps.2019.11.024
  • Journal Name: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals
  • Page Numbers: pp.215-219
  • Keywords: MDR1, BCRP, COX-2, Breast cancer, Genetic susceptibility, Genotype analysis, SINGLE NUCLEOTIDE POLYMORPHISMS, MDR1 C3435T POLYMORPHISM, PROSTATE-CANCER, P-GLYCOPROTEIN, EXPRESSION, CYCLOOXYGENASE-2, TRANSPORTERS, RESISTANCE, SUSCEPTIBILITY, CHEMOTHERAPY
  • Istanbul University Affiliated: Yes

Abstract

Aim: Breast cancer is the most common cancer and the second leading cause of cancer-related deaths among women. Several genetic and environmental factors are known to be involved in breast cancer pathogenesis, but the exact etiology of this disease is complicated and not completely understood. We aimed to investigate whether the gene polymorphisms of ABCB1 and ABCG2 carrier proteins and COX-2 enzyme affect breast cancer risk.