Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant.

CIFTCI H., Demir E., KARADENIZ M., TEFIK T., NANE I., OGUZ F., ...More

Renal failure, vol.40, no.1, pp.395-402, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/0886022x.2018.1489285
  • Journal Name: Renal failure
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.395-402
  • Keywords: Pharmacokinetic, renal transplantation, rejection, blood concentrations, UGT polymorphism, RESISTANCE-ASSOCIATED PROTEIN-2, UGT1A9 GENE, RECIPIENTS, MOFETIL, IMPACT, EXPOSURE, IDENTIFICATION, METABOLISM, PROMOTER, PLASMA
  • Istanbul University Affiliated: Yes

Abstract

Background: There are differences in pharmacokinetic of mycophenolic acid among individuals. The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms in the UGT1A9 gene may be responsible for individual differences in the pharmacokinetics of MPA. The aim of this study was to explain MPA pharmacokinetics in UGT1A9 1399 C > T polymorphisms in Turkish renal transplant patients.