Renal failure, vol.40, no.1, pp.395-402, 2018 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Pharmacokinetic, renal transplantation, rejection, blood concentrations, UGT polymorphism, RESISTANCE-ASSOCIATED PROTEIN-2, UGT1A9 GENE, RECIPIENTS, MOFETIL, IMPACT, EXPOSURE, IDENTIFICATION, METABOLISM, PROMOTER, PLASMA
Istanbul University Affiliated:
Background: There are differences in pharmacokinetic of mycophenolic acid among individuals. The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms in the UGT1A9 gene may be responsible for individual differences in the pharmacokinetics of MPA. The aim of this study was to explain MPA pharmacokinetics in UGT1A9 1399 C > T polymorphisms in Turkish renal transplant patients.