Atıf İçin Kopyala
Bahat-Öztürk G., İlhan B., Çapan N., Kılıç C., Yaşa C., Güngör Uğurlucan F., ...Daha Fazla
40th ESPEN Congress. On Clinical Nutrition&Metabolism., Madrid, İspanya, 1 - 04 Eylül 2018, ss.90
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Yayın Türü:
Bildiri / Tam Metin Bildiri
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Basıldığı Şehir:
Madrid
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Basıldığı Ülke:
İspanya
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Sayfa Sayıları:
ss.90
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İstanbul Üniversitesi Adresli:
Evet
Özet
Rationale: The objective of this study is to determine the effect of additional oral glutamine supplementation to Kegel exercise on pelvic floor strength and clinical parameters of urinary incontinence in females.
Methods: It is a randomized, double-blind study.Digital test and a vaginal manometer were used for measuring the strength of the pelvic floor muscles.24 hours pad weight test was examined.Participants were randomized into 2 groups as oral Glutamine 30 gr/day and placebo.It was asked to use the supplemantation and Kegel exercises to all participants for 3 months.Basic and 3th month measurements were compared by Paired sample T –test and Wilcoxon tests in each group.The progression between measurements at basic and 3th months was compared between the groups by using Mann-Whitney-U test.(Clinical Trials protokol ID: 2014/1203)
Results: There were 11 patients in the glutamine arm and 18 patients in the placebo arm.Mean age was 58.2±6.6 years.Mean body-mass-index was 32.9±4.8kg/m2.There was no age difference between the groups[glutamine 59±3.8,placebo 57.8±7.9 years,p>0.05].In glutamine arm,vaginal muscle strength assessed by digital test was higher at the end of 3 months [2.9±0.7 ve 4±0.9;0–3 months respectively, p=0.014];perinemeter measurements were not statistically different[27.4±8.3 ve 31.2±8.9; 0-3 months respectively,p>0.05];24 hour pad weight was not different [p>0.05].In placebo arm,there was statistically significant progress in vaginal muscle strength assessed by both digital test and perinemeter,and 24 hour pad weight(p values:0.005,0.011,0.002,respectively).When we compare the progression scores between the groups; there was no statistically significant difference [p>0.05].
Conclusions: Our study suggests that glutamine supplementation does not provide additional benefit in the treatment of pelvic muscle sarcopenia in patients without protein-energy malnutrition.