High-dose piracetam is effective on cerebellar ataxia in a patient with cerebellar cortical atrophy

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Vural M., Ozekmekci S., Apaydin H., Altinel A.

MOVEMENT DISORDERS, vol.18, no.4, pp.457-459, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1002/mds.10364
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.457-459
  • Istanbul University Affiliated: Yes


We report on a patient with spontaneous and stimulus-

sensitive myoclonic jerks and dystonia of the right leg that

had been present since infancy. Magnetic resonance imaging

showed a linear area of gliosis confined to the left posterolateral

putamen. This is the first report of focal myoclonus-dystonia of

the lower limb secondary to a putaminal lesion.

We describe a patient with cerebellar ataxia of degenerative nature who was administered high-dose piracetam in a single-blind trial. Piracetam was demonstrated to be highly effective on tandem gait and gait ataxia in daily doses of 60 g. We suggest piracetam has a potential anti-ataxic effect in human cerebellar ataxia when used in considerably higher doses than those indicated for other purposes. (C) 2003 Movement Disorder Society.