Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen

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Kürkçüoğlu M., Işcan G., Tosun F., Miski M.

ACTA PHARMACEUTICA SCIENCIA, vol.61, no.1, pp.81-90, 2023 (Scopus)

  • Publication Type: Article / Article
  • Volume: 61 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.23893/1307-2080.aps6106
  • Journal Indexes: Scopus, Chemical Abstracts Core
  • Page Numbers: pp.81-90
  • Istanbul University Affiliated: Yes


The hydrodistilled essential oils of the dried fruits of F. halophila Peşmen, an endemic species growing near Salt Lake in Central Anatolia, were analyzed by GC and GC-MS systems; 27 and 24 compounds representing 92.1% and 79.8% of the essential oils were characterized, respectively. The main component of the essential oils was identified as β-phellandrene. The antibacterial and anticandidal effects of the essential oils were determined by using partly modified CLSI methods M7-A7 and M27-A2, respectively. The essential oils from two specimens showed weak to moderate inhibitory effects on the tested pathogenic bacteria (MIC, 125-2000 μg/ mL) and Candida panels (MIC, 156-1250 μg/mL).