Effects of zinc oxide nanoparticles on bioaccumulation and oxidative stress in different organs of tilapia (Oreochromis niloticus)

Kaya H., Aydin F., GÜRKAN M., YILMAZ S., ATEŞ M., DEMİR V., ...Daha Fazla

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.40, sa.3, ss.936-947, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.etap.2015.10.001
  • Dergi Adı: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.936-947
  • Anahtar Kelimeler: ZnO nanoparticles, Toxicity, Oxidative stress, Accumulation, Tilapia (Oreochromis niloticus), CARP CYPRINUS-CARPIO, TITANIUM-DIOXIDE NANOPARTICLES, BIOTIC LIGAND MODEL, ONCORHYNCHUS-MYKISS, DIETARY EXPOSURE, RAINBOW-TROUT, ZNO NANOPARTICLES, LEAD-EXPOSURE, TOXICITY, CADMIUM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Nano-size zinc oxide particles (ZnO NPs) are used in diverse industrial and commercial fields. However, the information from existing studies is not sufficient in evaluating the potential toxic effects of ZnO NPs. In this study, tilapia fish (Oreochromis niloticus) were exposed to different concentrations of small and large ZnO NPs in vivo. Accumulation in various organs/tissues (liver, gill, intestine, kidney, brain and muscle) and possible oxidative stress mechanisms were investigated comparatively. Fish were exposed to 1 and 10 mg/L concentrations of small (10-30 nm) and large (100 nm) ZnO NPs semi-statically for 14 days. Both small and large ZnO NPs accumulated substantially in the tissues. Accumulation for the small ZnO NPs was significantly higher compared to larger NPs under same exposure regimes. Significant fluctuations were observed in antioxidant defense system biomarkers, including Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) levels depending on particle size, exposure time and concentration. Lipid peroxidation measured with TBARS levels were higher in groups exposed to the suspensions of small ZnO NPs than that of large ZnO NPs and controls. These results imply that colloidal suspensions of small ZnO NPs induce elevated oxidative stress and toxic effects on tilapia compared to the larger NPs. (C) 2015 Elsevier B.V. All rights reserved.