The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures

Sag A. A., Sal O., Kilic Y., Onal E. M., Kanbay M.

JOURNAL OF CLINICAL HYPERTENSION, vol.19, no.5, pp.530-533, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 19 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1111/jch.12978
  • Journal Name: JOURNAL OF CLINICAL HYPERTENSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.530-533
  • Istanbul University Affiliated: No

Abstract

This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.