Inflammation and Neurodegeneration in Patients with Early-Stage and Chronic Bipolar Disorder

Karabulut S., Tasdemir I., Akcan U., Kucukali C. I., Tuzun E., Cakir S.

TURK PSIKIYATRI DERGISI, vol.30, no.2, pp.75-81, 2019 (SSCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.5080/u18376
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.75-81
  • Keywords: Bipolar disorder, inflammatory cytokines, neuron-specific enolase, S100B, neuroinflammation, CEREBROSPINAL-FLUID, OXIDATIVE STRESS, S100B PROTEIN, MANIC EPISODE, SERUM-LEVELS, ENOLASE NSE, DEPRESSION, LITHIUM, BIOMARKERS, CYTOKINES
  • Istanbul University Affiliated: Yes


Objective: The increase in the circulatory cytokine levels observed in patients with bipolar disorder (BD) may imply involvement of inflammation in the pathogenesis of mood disorders. However, the association between the inflammatory process and the stage and severity of illness is not well understood. In this study, our aim was to investigate the association between neuroinflammation and disease progression in the clinical course of BD.