Inflammation and Neurodegeneration in Patients with Early-Stage and Chronic Bipolar Disorder

Karabulut S., Tasdemir I., Akcan U., Kucukali C. I., Tuzun E., Cakir S.

TURK PSIKIYATRI DERGISI, cilt.30, sa.2, ss.75-81, 2019 (SSCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5080/u18376
  • Dergi Adı: TURK PSIKIYATRI DERGISI
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-81
  • Anahtar Kelimeler: Bipolar disorder, inflammatory cytokines, neuron-specific enolase, S100B, neuroinflammation, CEREBROSPINAL-FLUID, OXIDATIVE STRESS, S100B PROTEIN, MANIC EPISODE, SERUM-LEVELS, ENOLASE NSE, DEPRESSION, LITHIUM, BIOMARKERS, CYTOKINES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The increase in the circulatory cytokine levels observed in patients with bipolar disorder (BD) may imply involvement of inflammation in the pathogenesis of mood disorders. However, the association between the inflammatory process and the stage and severity of illness is not well understood. In this study, our aim was to investigate the association between neuroinflammation and disease progression in the clinical course of BD.