Assessment of p53 and Bcl-2 Protein Expressions in Oral Lichen Planus and Oral Squamous Cell Carcinoma

Soluk Tekkeşin M., Sinanoğlu A., Aksakallı F. N.

17th International Congress on Oral Pathology and Medicine Joint Meeting of the British Society for Oral & Maxillofacial Pathology, 23 Eylül 2004 - 30 Mayıs 2016, cilt.119, sa.3, ss.191

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 119
  • Doi Numarası: 10.1016/j.oooo.2014.07.392
  • Sayfa Sayıları: ss.191
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective

Malignant transformation is suggested to be a consequence of alterations in cell cycle control, and this potential of oral lichen planus (OLP) is still controversial. The aim of this study was to evaluate the malignant transformation of OLP comparing with oral squamous cell carcinoma (OSCC) by immunohistochemistry.

Study Design

Bcl-2 and p53 expressions were determined by immunohistochemistry in 100 oral mucosal biopsies including normal oral mucosa (n=20), OLP (n=40) and OSCC (n=40).

Results

There were no significant differences in p53 and bcl-2 expressions between OLP and OSCC cases. However p53 expression was higher in OLP and OSCC compared to normal epithelium (p<0.05).

Conclusions

The results of this study suggest that the expression of these proteins might be an evidence of the potential of malignant transformation process in OLP. Therefore, there is a need for long term follow-up of patients with OLP to detect any malignant alteration.

Keywords

lichen planus, bcl-2, p53, oral squamous cell carcinoma