Allogeneic versus autologous versus peripheral stem cell transplantation in CR1 pediatric AML patients: A single center experience

Anak S., Saribeyoglu E., Bilgen H., Unuvar A., Karakas Z., Devecioglu O., ...Daha Fazla

PEDIATRIC BLOOD & CANCER, cilt.44, sa.7, ss.654-659, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/pbc.20256
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.654-659
  • Anahtar Kelimeler: allogeneic, autologous, bone marrow transplantation, chemotherapy, childhood AML, first remission, outcome, ACUTE MYELOID-LEUKEMIA, BONE-MARROW-TRANSPLANTATION, ACUTE MYELOGENOUS LEUKEMIA, ACUTE NONLYMPHOCYTIC LEUKEMIA, CHILDRENS CANCER GROUP, 1ST COMPLETE REMISSION, PROGNOSTIC-FACTORS, ONCOLOGY-GROUP, POSTREMISSION CHEMOTHERAPY, MAINTENANCE THERAPY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Treatment of childhood acute myelocytic leukemia (AML) in first remission, is still evolving. Allogeneic bone marrow transplantation (BMT) in patients with a donor has been well established, but the role of autologous transplantation remains of interest, particularly in the light of some encouraging results in adults. Procedure. Out of 81 pediatric patients with AML in first CR, 67 were biologically randomized for allogeneic (n = 31), autologous (n = 20), or peripheral stem cell transplant (n = 16) after completing consolidation treatment, with the remaining (n = 11) dropping out or receiving chemotherapy. Disease free survival (DFS) of these different groups were analyzed. Results. Allogeneic transplantation is not superior to autologous and autologous peripheral blood stem cell transplantation (PBSCT) (DFS in 5 years is 61%, 50%, and 75%). The 5 years DFS in the autologous PBSCT group is significantly better than in the autologous BMT group (75% vs. 50%, P < 0.05). Conclusion. In pediatric AML patients without a donor, autologous BMT or autologous PBSCT appears to be an effective treatment option with low transplant related mortality especially in less privileged countries where the chemotherapy only results are still low. (c) 2005 Wiley-Liss, Inc.