Association of ITLN1 rs2274907 gene polymorphism and serum intelectin-1 level with Hypertension in cross-sectional study


Geyik F., Can G.

37. Uluslararası Katılımlı Kardiyoloji Kongresi, Antalya, Turkey, 18 - 21 November 2021, pp.57

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.57
  • Istanbul University Affiliated: Yes

Abstract

Background and Aim: Intelectin-1 also known as an endothelial lectin HL-1, is highly and selectively expressed in visceral adipose tissue. It has vasodilation and anti-inflmamation effects on isolated blood vessels through endothelium-derived nitric oxide. High blood pressure causes increased inflammatory activity and endothelial dysfunction. In this study, it was aimed to investigate the relationship between ITLN1 rs2274907 A>T polymorphism and serum intelectin-1 leves with hypertension. Methods: The genotype analysis was performed using LightSNiP assay in a group of 1260 hypertensive and 1003 non-hypertensive individuals participating in the “Turkish Adults Risk Factors (TARF)” cohort study. Results: The genotype distributions of rs2274907 A>T polymorphism in the hypertensive individuals were 53.7% (n=677) for AA, 38.8% (n=488) for AT and 7.6% (n=95) for TT genotypes, while 49.9% (n=501) for AA, 41.9% (n=420) for AT and 8.2% (n=82) for TT in non-hypertensive individuals. There were no significant differences in genotype and allele distributions between two groups (p>0.05). However, serum intelectin-1 levels were higher in hypertensive men than non-hypertensive men (p=0.004). In addition, TT genotype was found to be associated with increased total cholesterol (p=0.010) in hypertensive male individuals. Conclusions: Our results suggest that the ITLN1 rs2274907 A>T gene polymorphism may not be associated with the risk of hypertension in the Turkish population, but may have an effect on serum intelectin-1 levels