Akademik Veri Yönetim Sistemi
37. Uluslararası Katılımlı Kardiyoloji Kongresi, Antalya, Türkiye, 18 - 21 Kasım 2021, ss.57
Background and Aim: Intelectin-1 also known as an endothelial lectin HL-1, is highly and selectively expressed in visceral
adipose tissue. It has vasodilation and anti-inflmamation effects on isolated blood vessels through endothelium-derived
nitric oxide. High blood pressure causes increased inflammatory activity and endothelial dysfunction. In this study,
it was aimed to investigate the relationship between ITLN1
rs2274907 A>T polymorphism and serum intelectin-1 leves
with hypertension.
Methods: The genotype analysis was performed using
LightSNiP assay in a group of 1260 hypertensive and 1003
non-hypertensive individuals participating in the “Turkish
Adults Risk Factors (TARF)” cohort study.
Results: The genotype distributions of rs2274907 A>T
polymorphism in the hypertensive individuals were 53.7%
(n=677) for AA, 38.8% (n=488) for AT and 7.6% (n=95) for
TT genotypes, while 49.9% (n=501) for AA, 41.9% (n=420)
for AT and 8.2% (n=82) for TT in non-hypertensive individuals. There were no significant differences in genotype
and allele distributions between two groups (p>0.05).
However, serum intelectin-1 levels were higher in hypertensive men than non-hypertensive men (p=0.004). In
addition, TT genotype was found to be associated with
increased total cholesterol (p=0.010) in hypertensive
male individuals.
Conclusions: Our results suggest that the ITLN1 rs2274907
A>T gene polymorphism may not be associated with the risk
of hypertension in the Turkish population, but may have an
effect on serum intelectin-1 levels