Guaianolide sesquiterpene lactones from Cichorium intybus (Asteraceae)


DENG Y., SCOTT L., SWANSON D., SNYDER J., SARI N. , Dogan H. H.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, cilt.56, ss.787-796, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 56 Konu: 8
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1515/znb-2001-0812
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Sayfa Sayıları: ss.787-796

Özet

Ten guaianolides, including three previously unreported natural products, were isolated from the aerial parts of Cichorium intybus (Asteraceae), more commonly known as chicory. Two of the new compounds (8 and 9) were analogues of lactupicrin and 11 beta ,13-dihydrolactupicrin, respectively, with the C-15 oxidized to the aldehyde state. The third new natural product, which we have called intybulide A (10), is an isomer of lactucin with the lactone closed to the C-8 oxygen rather than the C-6.