Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study

Sehitoglu E., Cavus F., Ulusoy C., Kucukerden M., Orcen A., Akbas-Demir D., ...Daha Fazla

INFLAMMATION RESEARCH, sa.10, ss.799-801, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00011-014-0754-0
  • Dergi Adı: INFLAMMATION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.799-801
  • Anahtar Kelimeler: Anti-neuronal antibody, Autoantibody, Multiple sclerosis, Radiologically isolated syndrome, Protein macroarray, RYANODINE RECEPTORS, STRESS, CELLS
  • İstanbul Üniversitesi Adresli: Evet

Özet

To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS). Sera of 13 RIS patients were screened by a protein macroarray derived from human fetal brain cDNA library. Sequencing of a clone with the highest signal intensity revealed sorcin as a potential target autoantigen in RIS patients. ELISA studies showed high-titer sorcin-antibodies in 3 of 4 RIS patients who converted to RRMS in a 5-year follow-up period and 13 of 23 control RRMS patients. The value of sorcin antibody as a predictor of conversion from RIS to RRMS requires to be tested in larger prospective studies.