Vitamin D mitigates atherosclerosis risk in TNF-alpha-induced endothelial cells

Onal B., ALAYLIOĞLU M., DURSUN E., GEZEN AK D.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, cilt.21, sa.4, ss.701-706, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4314/tjpr.v21i4.3
  • Dergi Adı: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.701-706
  • Anahtar Kelimeler: Atherosclerosis, Cytokines, Vitamin D, Inflammation, TNF-alpha, INFLAMMATORY CYTOKINES, CARDIOVASCULAR-DISEASE, D SUPPLEMENTATION, D DEFICIENCY, PREVENTION, TRIAL
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Purpose: To determine the effect of vitamin D on endothelial function in a cell line model of inflammation. Methods: Human saphenous vein cells were treated with 1,25-dihydroxyvitamin D3 (1,25-OHD) and/or TNF-??, and the expression levels of 20 different atherosclerotic cytokines were examined in the treated cells using a human atherosclerosis antibody array. The STRING and PANTHER analyses were also performed to determine the possible pathway interactions of these four pro-atherosclerotic and two antiResults: The expression levels of pro-atherosclerotic cytokines GM-CSF, CCL20, CCL5, and TNF-?? decreased upon 1,25-OHD administration, whereas those of anti-atherosclerotic cytokines PDGFB and Conclusion: Vitamin D could mitigate cardiovascular risks by mediating the expression of inflammatory cytokines; however, this needs to be verified via in vivo studies.