Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg


POWELL K. L. , TANG H., NG C., GUILLEMAIN I., DIEUSET G., DEZSI G., et al.

EPILEPSIA, cilt.55, ss.1959-1968, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 55 Konu: 12
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/epi.12840
  • Dergi Adı: EPILEPSIA
  • Sayfa Sayısı: ss.1959-1968

Özet

ObjectiveOriginally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric characteristics of four main GAERS colonies that are being actively studied internationally: two from Melbourne (MELB and STRAS-MELB), one from Grenoble (GREN), and one from Istanbul (ISTAN).