PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia

Creative Commons License

Küçükcankurt F., Erbilgin Y., Fırtına S., Hatırnaz N., Karakaş Z., Celkan T., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.37, no.2, pp.98-103, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.4274/tjh.galenos.2019.2019.0282
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.98-103
  • Keywords: T-ALL, PTEN, AKT1, Next-generation sequencing, EXPRESSION, NOTCH1, IMPACT, ABNORMALITIES, RESISTANCE, MUTATIONS, PROGNOSIS, CANCERS, PI3K
  • Istanbul University Affiliated: Yes

Abstract

Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the clinical findings.