PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia

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Küçükcankurt F., Erbilgin Y., Fırtına S., Hatırnaz N., Karakaş Z., Celkan T., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.37, sa.2, ss.98-103, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjh.galenos.2019.2019.0282
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.98-103
  • Anahtar Kelimeler: T-ALL, PTEN, AKT1, Next-generation sequencing, EXPRESSION, NOTCH1, IMPACT, ABNORMALITIES, RESISTANCE, MUTATIONS, PROGNOSIS, CANCERS, PI3K
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the clinical findings.