Marriage is a spiritual and physical union of two people, supposed to last for a lifetime. According to Turkish Civil Law article 136, couples are obliged by municipal authorities to get a medical report in order to get permission to marry. In this context, although it varies among regions, some biochemical evaluations are required from couples at the time of admission. This study evaluates the laboratory parameters of the couples who admitted to outpatient clinic of Family Medicine at Istanbul Medeniyet University Goztepe Training and Research Hospital between years 2012-2013 in order to get medical report. Among 290 applicants evaluated 148 were women. There was no clinical or laboratory finding for VDRL, AntiHCV or radiological tuberculosis positivity. Two applicants had positivity for AntiHIV and 7 applicants had positive HBsAg. In accordance with these findings, the importance of giving counseling is obvious rather than only evaluating the health situations of these couples. It is obvious that efficient counseling provides the generation of a healthy population by helping the couples avoid genetically or sexually transmitted diseases. Therefore 'to protect the unborn offspring and achieve a healthier population' is both the responsibility and the 'chance' of the primary care system and the physician.