Intravenous immunoglobulins prevent the breakdown of the blood-brain barrier in experimentally induced sepsis

Esen, Figen; Senturk, Evren; Ozcan, Perihan; Ahishali, Bülent; Arican, Nadir; Orhan, Nurcan; Ekizoglu, Oğuzhan; Kucuk, Mutlu; Kaya, Mehmet

doi:10.1097/ccm.0b013e31823779ca

Intravenous immunoglobulins prevent the breakdown of the blood-brain barrier in experimentally induced sepsis

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Esen F., Senturk E., Ozcan P. E., Ahishali B., Arican N., Orhan N., ...More

CRITICAL CARE MEDICINE, vol.40, no.4, pp.1214-1220, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 40 Issue: 4
Publication Date: 2012
Doi Number: 10.1097/ccm.0b013e31823779ca
Journal Name: CRITICAL CARE MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1214-1220
Keywords: blood-brain barrier, immunoglobulin A, immunoglobulin G, immunoglobulin M, sepsis, NECROSIS-FACTOR-ALPHA, SEPTIC ENCEPHALOPATHY, IN-VITRO, LIPOPOLYSACCHARIDE, INHIBITION, PERMEABILITY, PATHOGENESIS, INFLAMMATION, ACTIVATION, ANTIBODIES
Istanbul University Affiliated: Yes

Abstract

Interventions: The effects of immunoglobulin G and immunoglobulins enriched with immunoglobulin A and immunoglobulin M on blood-brain barrier integrity and survival rates in septic rats were comparatively investigated.