Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz N., Tahan V., Sonsuz A., Eren F., Uraz S., Yuksel M., ...More

JOURNAL OF HEPATOLOGY, vol.47, no.6, pp.851-859, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jhep.2007.06.018
  • Journal Name: JOURNAL OF HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.851-859
  • Istanbul University Affiliated: Yes

Abstract

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).