Synthesis and anticonvulsant activity of some new arylidenehydrazides and 4-thiazolidinones

Ulusoy N., Ergenc N., Ekinci A., Ozer H.

MONATSHEFTE FUR CHEMIE, vol.127, no.11, pp.1197-1202, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 127 Issue: 11
  • Publication Date: 1996
  • Doi Number: 10.1007/bf00844695
  • Journal Name: MONATSHEFTE FUR CHEMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1197-1202
  • Istanbul University Affiliated: No

Abstract

A number of N,N'-bis(arylidene)mono(1-methylpropyl)malonic acid dihydrazides (3a-c), 1,1-bis[[(2-aryl-4-thiazolidinone-3-yl)amino]carbonyl]-2-methylbutanes (4a-e), and 1,1-bis[[3-alkyl/aryl-4-thiazolidinone-2-yl)hydrazono]carbonyl]-2-methylbutanes (6a-i) have been synthesized, characterized and evaluated for anticonvulsant activity. All tested compounds showed significant activity (10 to 60% protection) against pentylenetetrazole induced seizures.