Papillon-Lefevre syndrome - Analysis of peripheral blood lymphocyte subsets

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Firatli E., Gurel N., Efeoglu A.

JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.23, sa.9, ss.823-825, 1996 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 23 Sayı: 9
• Basım Tarihi: 1996
• Doi Numarası: 10.1111/j.1600-051x.1996.tb00618.x
• Dergi Adı: JOURNAL OF CLINICAL PERIODONTOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.823-825
• İstanbul Üniversitesi Adresli: Evet

Özet

We have studied the peripheral blood lymphocyte populations in our 6 patients (2 female and 4 male) with a mean age of 11.19 with Papillon-Lefevre Syndrome (PLS) using adequate monoclonal antibodies and double coloured flow cytometry. Total B, T, CD4, CD8, CD29, CD45RA, NK, HLA-DR cells were studied. Total B, T, CD4 and CD8 lymphocytes were within normal limits. We have observed an increase in the CD29 lymphocytes and NK cells and a decrease in CD45RA lymphocytes. We think that these findings are important in explaining B lymphocyte activation and in the pathogenesis of the PLS.