SPECTRAL CHARACTERIZATIONS AND ANTIBACTERIAL EFFECT OF 2-(5-R-1H-BENZIMIDAZOL-2-YL)-4-METHYL/BROMO-PHENOLS AND SOME METAL COMPLEXES

Tavman A., Ikiz S., Bagcigil A. F., Ozgur N. Y., Ak S.

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, cilt.24, sa.3, ss.391-400, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2010
  • Dergi Adı: BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.391-400
  • İstanbul Üniversitesi Adresli: Evet

Özet

2-(5-H/Cl/Me/NO2-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL1-HL5) were synthesized. HL1 complexes with Cu(NO3)(2), AgNO3, Zn(ClO4)(2) and; HL4, HL5 complexes with Zn(ClO4)(2) were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, H-1- and C-13-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin-G and oxytetracycline. While HL1 ligand has considerable antibacterial activity on B. cereus only; it's Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL5 and [Zn(HL5)(L-5)]ClO4 exhibit considerable high antibacterial activity toward K. pneumoniae, B. cereus, S. epidermidis and B. subtilis.