The protective role of melatonin in experimental hypoxic brain damage


Tutunculer F., Eskiocak S., Basaran U., Ekuklu G., Ayvaz S., Vatansever U.

PEDIATRICS INTERNATIONAL, cilt.47, sa.4, ss.434-439, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1442-200x.2005.02085.x
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Sayfa Sayıları: ss.434-439

Özet

Background: It is known that oxygen-derived free radicals play an important role in the pathogenesis of brain injury. Melatonin is a powerful scavenger of the oxygen free radicals. In this study, the protective effect of melatonin against the damage inflicted by reactive oxygen species during brain hypoxia was investigated in newborn rats using biochemical parameters.