Research Information System
Journal of Materials Science: Materials in Electronics, vol.35, no.10, 2024 (SCI-Expanded)
Sensitive and reliable detection of the amlodipine (AML) drug in biological and environmental samples poses a significant challenge, necessitating the development of innovative electrode platforms. Herein, efficient anodes (CuO@ITO) were constructed for the direct electrochemical detection of AML in phosphate buffer saline (PBS) by growing CuO nanostructures onto the ITO electrode. Controlled nucleation of Cu ions facilitated consistent structural growth over the ITO surface, resulting in close interfacial contact between the nanostructures and the current collector. The fabricated CuO@ITO anode exhibited remarkable electrochemical oxidation response toward AML, enabling sensitive detection within a dynamic concentration range of 0.1–1.6 µm using differential pulse voltammetry, with a detection limit of 0.014 µm. Additionally, the sensor demonstrated robust anti-interference capabilities against various biomolecules and pharmaceutical drugs, ensuring accurate and reliable AML detection even in complex biological samples. Satisfactory recoveries of spiked AML drug from human urine samples affirmed the sensor’s suitability for real-world applications. The overall findings of this work emphasize the significance of the developed sensor in enabling the sensitive and selective detection of AML, making it a valuable tool for clinical and environmental monitoring.