L-myc gene polymorphism and risk of thyroid cancer
Experimental Oncology, vol.30, no.2, pp.117-120, 2008 (Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 2
- Publication Date: 2008
- Journal Name: Experimental Oncology
- Journal Indexes: Scopus
- Page Numbers: pp.117-120
- Keywords: Allele, Cancer, L-myc, Polymorphism, Thyroid gland
- Istanbul University Affiliated: Yes
Abstract
L-myc gene polymorphism is a representative genetic trait responsible for an individual's susceptibility to several cancers. However, there have been no reports concerning the association between thyroid cancer and L-myc gene polymorphism. Aim: To analyze the distribution of L-myc gene polymorphism in Turkish patients with thyroid disorders and thyroid cancers. Methods: We used a molecular genotyping method, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). We studied 138 patients of whom 47 had multinodular goiter, 13 had follicular cancer and 69 had papillar cancer, in comparison with control group of 109 healthy individuals. Results: No significant difference in the distribution of genotypes was observed between thyroid patients and controls. Carrying SS or LS genotype revealed a 1.96-fold (95% CI 0.573-6.706) risk for the occurrence of follicular cancer when compared with controls, and 3.11-fold (95% CI 0.952-10.216), when compared with multinodular goiter patients (p = 0.04). Conclusion: We suggest that L-myc genotype profiling together with other susceptibility factors, may be useful in the screening for thyroid nodular malignancy. Copyright © Experimental Oncology, 2008.