Neurofibromatosis Type I and Hodgkin Lymphoma: Case Report and Review of the Literature


Yıldırım Ü. M., Kebudi R.

Turkish Archives of Pediatrics, vol.57, no.5, pp.566-568, 2022 (Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Review
  • Volume: 57 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.5152/turkarchpediatr.2022.22004
  • Journal Name: Turkish Archives of Pediatrics
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.566-568
  • Keywords: cancer predisposition, Hodgkin lymphoma, Neurofibromatosis, pediatrics
  • Istanbul University Affiliated: No

Abstract

Objective: Neurofibromatosis 1 is an autosomal dominant inherited tumor susceptibility syn-drome. Individuals with neurofibromatosis 1 have a 4-5 times increased risk of malignancy compared to the general population. Central nervous system and soft tissue tumors are common non-hematological malignancies in individuals with neurofibromatosis 1. Although the association of leukemia and non-Hodgkin lymphoma as hematologic malignancies in neurofi-bromatosis 1 has been reported frequently in the literature in these individuals, association with Hodgkin lymphoma has been reported very rarely. Materials and Methods: We presented a patient with neurofibromatosis 1 who further developed Hodgkin lymphoma and reviewed the literature. Conclusion: Although rare, Hodgkin lymphoma can develop in individuals with neurofibroma-tosis 1. Hodgkin lymphoma should be kept in mind in cervical/supraclavicular lymphadeno-megalies when evaluating patients with neurofibromatosis 1.