Ocular and generalized myasthenia gravis induced by human acetylcholine receptor ? subunit immunization
MUSCLE & NERVE, cilt.45, sa.2, ss.209-216, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1002/mus.22273
- Dergi Adı: MUSCLE & NERVE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.209-216
- Anahtar Kelimeler: acetylcholine receptor ? subunit, autoimmune disease, extraocular muscles, myasthenia gravis, ocular myasthenia gravis, HLA TRANSGENIC MICE, EXTRAOCULAR-MUSCLE, GENE-EXPRESSION, GAMMA-SUBUNIT, SKELETAL-MUSCLE, ALPHA-SUBUNIT, MOUSE MODEL, PATHOGENESIS, INDUCTION, MECHANISM
- İstanbul Üniversitesi Adresli: Evet
Özet
Introduction: HLA-DQ8 transgenic mice develop ocular myasthenia gravis (oMG), which then progresses to generalized MG (gMG) when immunized with the human acetylcholine receptor (H-AChR) a subunit. Because the fetal AChR ? subunit is expressed in adult extraocular muscles, we anticipated that ? subunit immunization would generate an immune response to mouse AChR and induce MG in mice. Results: H-AChR ? subunit immunization in HLA-DQ8 mice induced an autoimmune response to mouse AChR and led to the destruction of AChR in the neuromuscular junction (NMJ) by anti-AChR antibody and complement activation, and it triggered upregulation of AChR gene transcription. Conclusion: Our findings indicate that oMG may be induced by immunity to the AChR ? subunit. Muscle Nerve, 2012