Changes in the Expression of c-fos and AQP4 in the Hippocampus and Amygdala Regions of Rats with Kainic Acid-Induced Temporal Lobe Epilepsy and Their Role in the Pathogenesis of Disease


Taskiran E., Yilmaz C. U., Orhan N., Kaya M., Arican N., Bahceci M. B., ...More

ARCHIVES OF EPILEPSY, vol.28, no.2, pp.59-64, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.54614/archepilepsy.2022.220205
  • Journal Name: ARCHIVES OF EPILEPSY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.59-64
  • Keywords: fos, AQP4, epileptogenesis, temporal lobe epilepsy, animal model, kainic acid, AQUAPORIN-4, SEIZURES, MODEL, WATER, KAINATE, EPILEPTOGENESIS, POTASSIUM
  • Istanbul University Affiliated: Yes

Abstract

Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-fos and aquaporin4 during epileptogenesis after systemic kainic acid-induced status epilepticus in the temporal lobe epilepsy animal model and to investigate their alterations in both hippocampus and amygdala.