Changes in the Expression of c-fos and AQP4 in the Hippocampus and Amygdala Regions of Rats with Kainic Acid-Induced Temporal Lobe Epilepsy and Their Role in the Pathogenesis of Disease

Taskiran E., Yilmaz C. U., Orhan N., Kaya M., Arican N., Bahceci M. B., ...Daha Fazla

ARCHIVES OF EPILEPSY, cilt.28, sa.2, ss.59-64, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.54614/archepilepsy.2022.220205
  • Dergi Adı: ARCHIVES OF EPILEPSY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.59-64
  • Anahtar Kelimeler: fos, AQP4, epileptogenesis, temporal lobe epilepsy, animal model, kainic acid, AQUAPORIN-4, SEIZURES, MODEL, WATER, KAINATE, EPILEPTOGENESIS, POTASSIUM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-fos and aquaporin4 during epileptogenesis after systemic kainic acid-induced status epilepticus in the temporal lobe epilepsy animal model and to investigate their alterations in both hippocampus and amygdala.