Gender specific association of ABCA1 gene R219K variant in coronary disease risk through interactions with serum triglyceride elevation in Turkish adults

Coban N., Onat A., Bayrak E. K., Gulec Ç., Can G., Unaltuna N.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.14, sa.1, ss.18-25, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/akd.2013.234
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.18-25
  • Anahtar Kelimeler: ABCA1 gene variants, coronary heart disease risk, gender difference, phospholipids, serum triglycerides, Turkish population, regression analysis, HIGH-DENSITY-LIPOPROTEIN, CASSETTE TRANSPORTER A1, METABOLIC SYNDROME, CARDIOVASCULAR-DISEASE, CHOLESTEROL LEVELS, LOW HDL, POLYMORPHISM, EFFLUX, DEFINITION, PATHWAYS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: ATP binding cassette transporter A1 (ABCA1) controls the reverse cholesterol transport. Some ABCA1 variants are correlated with serum high-density lipoprotein cholesterol (HDL-C) and other lipid concentrations. We aimed to explore the relationship of ABCA1 gene with both the lipid profile and coronary heart disease (CHD) risk.