The role of miRNAs targeting K-ras and APC genes in colorectal cancer

Yilmaz N., Yilmaz U., Tanbek K., Arikan S., Aksakal N., Zeybek U., ...Daha Fazla

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.121, sa.8, ss.554-557, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4149/bll_2020_092
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.554-557
  • Anahtar Kelimeler: colorectal, cancer, miRNA, APC, K-ras, ADENOMATOUS-POLYPOSIS-COLI, TUMOR-SUPPRESSOR GENE, PROMOTES, CELL, MICRORNAS, MIR-217, DIFFERENTIATION, PROLIFERATION, BIOMARKERS, EXPRESSION
  • İstanbul Üniversitesi Adresli: Evet

Özet

OBJECTIVES: The occurrence of abnormal expression patterns in different types of cancer suggests that micro RNAs (miRNAs) may play an important role in tumorigenesis. The aim of this study was to examine the expression levels of miRNAs known to be associated with the regulation of the expression levels of the APC and K-ras, which are important in the development of colorectal cancer (CRC).