Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations


SPIERINGS E., HENDRIKS M., ABSI L., CANOSSI A., CHHAYA S., CROWLEY J., ...Daha Fazla

PLOS GENETICS, cilt.3, sa.6, ss.1108-1119, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1371/journal.pgen.0030103
  • Dergi Adı: PLOS GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1108-1119
  • İstanbul Üniversitesi Adresli: Evet

Özet

Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft- versus-host disease, and in the curative graft-versus- tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.