Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis


Gurses C., Azakli H., Alptekin A., Cakiris A., Abaci N., Arikan M., ...More

GENE, vol.538, no.2, pp.323-327, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 538 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1016/j.gene.2014.01.030
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.323-327
  • Keywords: Mesial temporal lobe epilepsy, Hippocampal sclerosis, MT-ND4, MT-ND5, MT-ATP8, LOW SPERM MOTILITY, SEQUENCE-ANALYSIS, MUTATION C11994T, ND4 GENE, HETEROPLASMY, INVOLVEMENT, GENERATION
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Mitochondria have an essential role in neuronal excitability and neuronal survival. In addition to energy production, mitochondria also play a crucial role in the maintenance of intracellular calcium homeostasis, generation of reactive oxygen species and mechanisms of cell death. There is a relative paucity of data about the role of mitochondria in epilepsy. Mitochondrial genome analysis is rarely carried out in the investigation of some diseases. In mesial temporal lobe epilepsies (MTLE) cases, genome analysis has never been used previously. The aim of this study is to show mitochondrial dysfunctions using genome analysis in patients with MTLE-hippocampal sclerosis (HS).