Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis


Gurses C. , Azakli H., Alptekin A., Cakiris A. , Abaci N., Arikan M., ...Daha Fazla

GENE, cilt.538, ss.323-327, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 538 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.gene.2014.01.030
  • Dergi Adı: GENE
  • Sayfa Sayıları: ss.323-327

Özet

Introduction: Mitochondria have an essential role in neuronal excitability and neuronal survival. In addition to energy production, mitochondria also play a crucial role in the maintenance of intracellular calcium homeostasis, generation of reactive oxygen species and mechanisms of cell death. There is a relative paucity of data about the role of mitochondria in epilepsy. Mitochondrial genome analysis is rarely carried out in the investigation of some diseases. In mesial temporal lobe epilepsies (MTLE) cases, genome analysis has never been used previously. The aim of this study is to show mitochondrial dysfunctions using genome analysis in patients with MTLE-hippocampal sclerosis (HS).