The Frequency of HLA Class I and II Alleles in Turkish Childhood Acute Leukaemia Patients

Ozdilli K., Oguz F., Anak S., Kekik Ç., Carin M., GEDIKOGLU G.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.38, sa.5, ss.1835-1844, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/147323001003800531
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1835-1844
  • Anahtar Kelimeler: ACUTE LEUKAEMIA, ACUTE MYELOID LEUKAEMIA (AML), ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL), CHILDREN, HUMAN LEUCOCYTE ANTIGEN (HLA), ACUTE LYMPHOBLASTIC-LEUKEMIA, MAJOR HISTOCOMPATIBILITY COMPLEX, CHRONIC LYMPHOCYTIC-LEUKEMIA, ACUTE MYELOGENOUS LEUKEMIA, RISK GROUPS, T-CELL, ANTIGENS, SUSCEPTIBILITY, IDENTIFICATION, ASSOCIATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study, blood samples were taken from 200 patients with childhood acute leukaemias, including acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML), and from 100 healthy volunteers (controls). The frequency of the human leucocyte antigen (HLA)-DRB1*04 allele was significantly higher, and the frequencies of the HLA-A23 and HLA-B7 antigens were significantly lower, in patients with ALL compared with controls. Among patients with AML, the frequency of the HLA-B49 antigen and the HLA-DRB1*15 allele were significantly higher, whereas the frequencies of the HLA-A11 and HLA-B38 antigens were significantly lower compared with controls. The frequency of the HLA-DRB1*04 allele was also significantly higher in male patients with ALL and AML, whereas the HLA-DRB1*13 allele was found significantly less frequently in male AML and female ALL patients than in controls. To date, this is the only study to evaluate the associations between HLA molecules and leukaemia in a Turkish population with acute childhood leukaemia.