Novelties in the management of B-cell malignancies: B-cell receptor signaling inhibitors and lenalidomide

Salihoglu A. , Ar M. C. , Soysal T.

EXPERT REVIEW OF HEMATOLOGY, cilt.8, ss.765-783, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1586/17474086.2015.1091301
  • Sayfa Sayıları: ss.765-783


B-cell lymphoproliferative disorders comprise 85% of Non-Hodgkin's lymphomas. Despite successful chemoimmunotherapy regimens, responses are not durable and the outcome is fatal in a considerable portion of patients. There is an inevitable need for less toxic and more potent therapeutic agents. Over the recent years, a plethora of agents including monoclonal antibodies, Bcl-2 antagonists, tyrosine kinase inhibitors, cyclin-dependent kinase inhibitors, mTOR inhibitors and immunomudulatory drugs have been developed in B-cell malignancies. The aim of this paper is to focus on B-cell receptor signaling inhibitors and lenalidomide as an immunomodulatory drug and to provide insight on how and when to incorporate these agents into the treatment algorithms.