Oxidative protein damage parameters in plasma in chronic experimental diabetes in rats


Kayali R., Telci A. , Cakatay U. , Karaca C., Akcay T. , Sivas A., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICAL RESEARCH, cilt.8, ss.307-312, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 7
  • Basım Tarihi: 2003
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.307-312

Özet

An increase in oxidative stress may contribute to the development of oxidative protein damage (OPD) in the streptozotocin-diabetic rat. To show the effect of hyperglycemia in promoting OPD, we determined protein carbonyl (PCO), nitrotyrosine (NT), total thiol (T-SH) and advanced oxidation protein product (AOPP) levels as markers of OPD, and lipid hydroperoxide (LHP) levels as a marker of lipid peroxidation in plasma of acute and chronic diabetic male Sprague-Dawley rats and their controls. The levels of the studied markers, except NT, were determined by colorimetric methods. NT levels were measured by ELISA.