Oxidative protein damage parameters in plasma in chronic experimental diabetes in rats

Kayali R., Telci A., Cakatay U., Karaca C., Akcay T., Sivas A., ...Daha Fazla

EUROPEAN JOURNAL OF MEDICAL RESEARCH, cilt.8, sa.7, ss.307-312, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 7
  • Basım Tarihi: 2003
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-312
  • İstanbul Üniversitesi Adresli: Evet

Özet

An increase in oxidative stress may contribute to the development of oxidative protein damage (OPD) in the streptozotocin-diabetic rat. To show the effect of hyperglycemia in promoting OPD, we determined protein carbonyl (PCO), nitrotyrosine (NT), total thiol (T-SH) and advanced oxidation protein product (AOPP) levels as markers of OPD, and lipid hydroperoxide (LHP) levels as a marker of lipid peroxidation in plasma of acute and chronic diabetic male Sprague-Dawley rats and their controls. The levels of the studied markers, except NT, were determined by colorimetric methods. NT levels were measured by ELISA.