Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis

Tuzun E., ROSSI J. E., KARNER S. F., CENTURION A. F., DALMAU J.

JOURNAL OF NEUROIMMUNOLOGY, cilt.186, ss.177-180, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 186
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jneuroim.2007.03.015
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.177-180
  • Anahtar Kelimeler: limbic encephalitis, paraneoplastic, adenylate kinase 5, antibodies, PROTEIN, IDENTIFICATION, AUTOANTIGEN, DISORDERS, DIVERSITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

We report two men with limbic encephalitis (LE) refractory to corticosteroids, Wig and plasma exchange. Both patients had serum/CSF antibodies that reacted with the cytoplasm of neurons. Probing of a hippocampal cDNA library resulted in the isolation of adenylate kinase 5 (AK5). Patients' antibodies, but not those of 111 controls, recognized AK5-expressing phage plaques. Human AK5-affinity purified antibodies reproduced the neuronal immunolabeling of patients' antibodies, and co-localized with a rabbit AK5 antibody, confirming that the brain autoantigen was AK5. Detection of antibodies to AK5 in LE patients carries a poor prognosis, and suggests the prompt use of aggressive immunosuppression. (c) 2007 Elsevier B.V. All rights reserved.