Mechanisms of Aeroallergen Immunotherapy Subcutaneous Immunotherapy and Sublingual Immunotherapy

Özdemir C., Kucuksezer U. C., AKDIS M., Akdiş C. A.

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, vol.36, no.1, pp.71-87, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.iac.2015.08.003
  • Journal Name: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.71-87
  • Keywords: Allergy, Allergens, Immunotherapy, T regulatory cells, Tolerance, ALLERGEN-SPECIFIC IMMUNOTHERAPY, GRASS-POLLEN IMMUNOTHERAPY, REGULATORY T-CELLS, INNATE LYMPHOID-CELLS, NATURAL-KILLER-CELLS, HISTAMINE-RECEPTOR 2, IMMUNE-RESPONSE, B-CELLS, MAST-CELL, TGF-BETA
  • Istanbul University Affiliated: Yes

Abstract

Allergen immunotherapy (AIT) is an effective way to treat allergic disorders, targeting the underlying mechanisms and altering the disease course by inducing a long-lasting clinical and immune tolerance to allergens. Although sublingual and subcutaneous routes are used in daily practice, many novel ways to decrease side effects and duration and increase efficacy have been pursued. Further studies are needed to develop biomarkers for the identification of AIT responder patients and also to use the developed knowledge in allergy prevention studies. Future directions in AIT include treatments for autoimmune diseases, chronic infections, organ transplantation, and breaking immune tolerance to cancer cells.