Inflammation increases MMP levels via PGE(2) in human vascular wall and plasma of obese women


Ozen G., Boumiza S., Deschildre C., Topal G., LONGROIS D., Jakobsson P. J., ...Daha Fazla

INTERNATIONAL JOURNAL OF OBESITY, cilt.43, sa.9, ss.1724-1734, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1038/s41366-018-0235-6
  • Dergi Adı: INTERNATIONAL JOURNAL OF OBESITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1724-1734
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and objectives: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft failure of coronary artery (CA) bypass grafts [internal mammary artery (IMA), saphenous vein (SV)]. In these inflammatory conditions, the release of prostaglandin E-2 (PGE(2)) is increased via the activity of inducible microsomal PGE synthase-1 (mPGES-1). Our aim was to investigate whether MMPs and their endogenous inhibitor (TIMPs) may be regulated by PGE(2) under inflammatory conditions in human vasculature and perivascular adipose tissue (PVAT), as well as in plasma of obese patients.